Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide- like Effect of Capparis spinosa Aqueous Extract in Normal Rats

The purpose of this study was to examine the diuretic effect of the aqueous extract of Capparis spinosa (Cs) at a dose of 500 mg kg h in normal rats. The aqueous extract was administred intravenously and the diuresis was followed within four hours after starting the treatment. Intravenous administration of aqueous Cs extract produced a significant increase on diuresis (p<0.001) and glomerular filtration rate from the second hour of treatment to the fourth hour (p<0.001). In addition, urinary Na+, Cland K + were significantly increased after two hours of Cs perfusion (p<0.01). Furosemide at a dose of 0.1 mg kg h had similar effect when compared to Cs administration. We conclude that the water extract of Cs fruit exhibited a significant diuretic effect accompanied by in crease in Na+, K+ and Clurinary excretion in normal rat. This effect may be mediated via a Furosemide like effect.